Captain Marvel: Earth's Mightiest Superhero Volume 2 written by Kelly Sue DeConnick with art by Scott Hepburn, Pat Olliffe, Matteo Buffagni, Filipe Andrade, Barry Hitson, et al.
Captain Marvel's brain lesion gets worse and worse (see the start of this story here), forcing her either to adapt her style or to sacrifice herself in order to continue being a hero. As she faces lots of old foes, the enemy causing the problem is finally discovered, along with his nefarious plan to destroy Captain Marvel and New York City. The story plays out at a good pace and has a very satisfying conclusion.
But wait, there's more! Captain Marvel fights alongside the Avengers and a coalition of aliens (Kree, Skrull, etc.) to stop the Builders, an ancient alien race that seems intent on wiping out the Earth. Interestingly, the book covers the same action twice, once from Captain Marvel's point of view, then from Spider-Woman's point of view. The differences are enough to make it interesting though I was surprised to see the same stuff twice. Unfortunately, the war doesn't really finish in this book which I found frustrating.
The book also has a Captain Marvel/Spider-man adventure in Boston with a young woman who isn't all she seems. The woman passes herself off as a superhero but doesn't know her own name (Spider-man makes some unhelpful but comic suggestions). The story is fun and does wrap up.